Obtención de moléculas bioactivas naturales y sintéticas

Proyectos

• Nodos de Innovación UV «Adquisición de equipo homogeneizador de alta presión y accesorios para trabajo en formulados nano» (2022). Coinvestigador
• FONDECYT Postdoctorado 3220105 «Sintesis de nuevos analogos de brasinoesteroides de cadena corta tipo 23,24-dinorcolano con esteres de benzoato 2,4 disustituidos y estudio de su actividad promotora del crecimiento vegetal» (2022). Investigador patrocinante
• Concurso de Investigacion en Docencia Universitaria UV «Maleta didactica tipo ABP para fortalecer la enseñanza de estereoisomeria en quimica organica» (2022). Coinvestigador
• FONDECYT Regular 1231502 «Design and synthesis of new brassinoesteroids analogs with benzoate groups at C-22. Assessment of effects on plant growth, and in silico studies of structure activity relationship» (2021-2024). Coinvestigador
• FONDECYT Regular 1201395 «Drimanic sesquiterpens and lichen metabolites as building block for the synthesis of new sesquiterpene-orcinol derivatives, as potential topoisomerase I/ II, and or PDK1 kinase inhibitors» (2019-2022). Investigador responsable

Publicaciones

• Araque I, et al. Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol. Molecules 2023; 28(9):3959. 10.3390/molecules28093959
• Bustos L, et al. Cytotoxic Effects on Breast Cancer Cell Lines of Chalcones Derived from a Natural Precursor and Their Molecular Docking Analysis. Molecules 2022, 27(14), 4387 10.3390/molecules27144387
• Espinosa-Bustos C, et al. New Amino Naphthoquinone Derivatives as Anti-Trypanosoma cruzi Agents Targeting Trypanothione Reductase. Pharmaceutics 2022, 14(6): 1121 10.3390/pharmaceutics14061121
• Mellado M, et al. QSAR-driven synthesis of antiproliferative chalcones against SH-SY5Y cancer cells: Design, biological evaluation, and redesign. Archiv der Pharmazie 2022, 355:e2200042. 10.1002/ardp.202200042
• Mellado M, et al. Combined 3D-QSAR and docking analysis for the design and synthesis of chalcones as potent and selective monoamine oxidase B inhibitors. Bioorganic Chemistry 2021, 108:104689 10.1016/j.bioorg.2021.104689
• Ferrer K, et al. Synthesis of New Brassinosteroid 24-Norcholane Type Analogs Conjugated in C-3 with Benzoate Groups Molecules 2021, 26(4), 1173. 10.3390/molecules26041173
• Madrid A, et al. Chemical Analysis and In Vitro Bioactivity of Essential Oil of Laurelia sempervirens and Safrole Derivatives against Oomycete Fish Pathogens. Molecules 2021, 26(21), 6551. 10.3390/molecules26216551
• Ogalde JP, et al. Análisis nutricional del maíz lluteño y caracterización de los ácidos grasos en muestras antiguas y modernas del norte de Chile. Interciencia: Revista de ciencia y tecnología de América 2020, 45(12)
• Mellado M, et al. Design, synthesis, antifungal activity, and structure–activity relationship studies of chalcones and hybrid dihydrochromane–chalcones. Molecular Diversity 2020 10.1007/s11030-019-09967-y 
• Mellado M, et al. Design, Synthesis and Docking Calculations of Prenylated Chalcones as Selective Monoamine Oxidase B Inhibitors with Antioxidant Activity. Chemistry Select 2019, 4, 7698. doi.org/10.1002/slct.201901282
• Russo A, et al. Antigrowth activity and induction of apoptosis in human melanoma cells by Drymis winteri forst extract and its active components. Chemico-Biological Interactions 2019, 25;305:79-85. 10.1016/j.cbi.2019.03.029.
• Quiñones N, et al. (-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of angucyclinones. Molecules 2018, 23(6), 1422 10.3390/molecules23061422
• Montenegro I, et al. Antifeedant effect of polygodial and drimenol derivatives against Spodoptera frugiperda and derivatives against Spodoptera frugiperda and Epilachna paenulata and quantitative structure-activity analysis.  Pest Management Science 2018, 74(7):1623-1629 10.1002/ps.4853
• Montenegro I, et al. Biopesticide Activity from Drimanic Compounds to Control Tomato Pathogens. Molecules 2018, 23(8), 2053. 10.3390/molecules23082053
• Mellado M, et al.  Synthesis of chalcones with antiproliferative activity on the SH-SY5Y neuroblastoma cell line: Quantitative Structure–Activity. Medicinal Chemistry Research 2018, 27, 2414–2425 10.1007/s00044-018-2245-2
• Mellado M, et al. Hansch’s analysis application to chalcone synthesis by Claisen–Schmidt reaction based in DFT methodology. Chemical papers 2018, 72, 703-709 10.1007/s11696-017-0316-3
• Apablaza G, et al. 2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human β3-Adrenergic Activity. Molecules 2017, 22(3), 404. 10.3390/molecules22030404